Обзор биологической активности флавоноидов: кверцетина и кемпферола

Обзор биологической активности флавоноидов: кверцетина и кемпферола

Автор: Чиряпкин А.С., Золотых Д.С., Поздняков Д.И.

Журнал: Juvenis scientia @jscientia

Рубрика: Обзорные статьи

Статья в выпуске: 2 т.9, 2023 года.

Бесплатный доступ

Флавоноиды представляют собой обширный класс вторичных метаболитов растений, которые содержатся в разной концентрации во многих их частях. С давних времён лекарственное сырье, содержащее флавоноиды, используется в традиционной медицине различных стран, а также применяется в современной медицине для создания лекарственных препаратов. В сравнении с другими группами вторичных метаболитов флавоноиды часто присутствуют в достаточно больших количествах. Интерес к флавоноидам обусловлен постоянно обновляемыми данными об их биологической активности, а также широким распространением в растительном мире. В настоящем обзоре освещаются два наиболее часто встречающихся полифенольных соединения в растениях - кверцетин и кемпферол. В статье описаны основные гликозидные формы рассматриваемых флавоноидов и современные результаты изучения их биологической активности, а именно антиоксидантной, противоаллергической, противовоспалительной, кардиопротекторной и противоопухолевой. Кроме того, обсуждаются некоторые механизмы реализации выше приведённых видов биологического действия. Из осуществлённого анализа следует, что перспективно дальнейшее более углубленное фармакологическое исследование этих флавоноидов и разработка на их основе новых передовых лекарственных препаратов. Ядра кверцетина и кемпферола можно рекомендовать для химической модификации с целью получения высокоактивных соединений с антиоксидантной, противоаллергической, противовоспалительной, кардиопротекторной и противоопухолевой активностью.

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Флавоноиды, кверцетин, кемпферол, гликозидные формы, биологическая активность, антиоксидантная активность, противоаллергическая активность, противовоспалительная активность, кардиопротекторная активность, противоопухолевая активность, механизмы действия, лекарственные препараты, химическая модификация

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Короткий адрес: https://sciup.org/14128034

IDR: 14128034   |   DOI: 10.32415/jscientia_2023_9_2_5-20

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