Assessment of functional status of blood leukocytes, lipid peroxidation system and antioxidant protection in patients with unstable angina

Objective. The purpose of the study is to trace the time history of leukocytes functional activity index and lipid peroxidation system - antioxidant protection in patients with unstable angina. Material and Methods. Using random sampling technique 46 patients with coronary artery disease were examined during this study. In the majority of cases CAD manifestations were in the form of progressive unstable angina. Assessment of the lipid peroxidation system - antioxidant protection was carried out thrice by dynamic study of malondialdehyde (MDA), catalase and glutathione reductase in blood and erythrocytes and of superoxide dismutase in erythrocytes only. Assessment of functional status of blood leukocytes was conducted twice using T.F Shevchenko and A.B. Peskov method (1996): on admission to hospital and on the 10th day of multimodal therapy. Results and Discussion. The results obtained suggest that during the acute phase and on the 10th day of hospital service there is high functional activity of peripheral blood leukocytes and transient changes in the activity of lipid peroxidation system and antioxidant protection in erythrocytes and plasma. Oxidative stress was observed only in patients with prolonged angina status and related non-contagious disease. Conclusions. Patients with unstable angina demonstrate significant increase in functional activity of blood leukocytes. Multimodal drug hospital therapy provides complete resetting of leukocytes functional activity index. Increase of blood leukocytes functional activity correlates with increase of lipids peroxidation system activity. However, due to the simultaneous activation of antioxidant protection patients with unstable angina do not demonstrate oxidative stress. Therefore, administration of exogenous antioxidants to such patients is inadvisable.