Evaluation of the Effectiveness of Benralizumab in a Patient with Severe Bronhial Asthma

Introduction. Severe bronchial asthma is a form of bronchial asthma that is difficult to treat, characterized by the uncontrollability of symptoms despite strict adherence to therapy and treatment of comorbidities. It may worsen with a reduction in high doses of glucocorticosteroids. The majority of patients with this pathology exhibit the eosinophilic phenotype, which is distinguished by a pronounced severity of the disease, a high frequency of exacerbations, and reduced effectiveness to standard anti-inflammatory therapy. Suppression of eosinophil activity represents a promising direction for the pathogenetic therapy of severe bronchial asthma. In recent decades, active research has focused on the study of gene-engineered biological drugs, which have proven their efficacy. The aim of the study is to evaluate the effectiveness of gene-engineered biological therapy, using the example of benralizumab administration in a patient suffering from severe bronchial asthma and chronic polypoid rhinosinusitis. Materials and methods. The article presents a clinical case of a 55-year-old female patient, A., diagnosed with “Bronchial asthma, non-allergic, severe course. Stage 1 chronic polypous rhinosinusitis”. The investigation utilized clinical, laboratory, and instrumental methods, as well as consultations with specialists. Results. In patient A., prolonged therapy with the 5th treatment stage did not achieve complete disease control. The gene-engineered biological therapy, using benralizumab 30 mg subcutaneously once every 3 weeks (for the first 3 doses), followed by 30 mg subcutaneously once every 4 weeks, demonstrated positive dynamics: stabilization of the patient's condition, a reduction in the frequency of exacerbations and nocturnal asthma attacks, a decrease in the need for hospitalization, and normalization of laboratory and instrumental parameters. Discussion and conclusion. The presented clinical case emphasizes the importance of studying and incorporating new genetically engineered biological agents into medical practice. The article will be of interest to physicians, as the use of modern treatment methods will allow for better disease prognosis and improve patients’ quality of life.