Assessment of lipid status in patients with stable coronary artery disease directed to coronary angioplasty and stenting

Lipid metabolism disturbances can maintain a local inflammatory response at the site of stent implantation and be unfavorable background for the restoration of the intima and the prevention of restenosis and stent thrombosis in the long term. Evaluated markers of lipid metabolism in 120 patients stable coronary artery disease who underwent coronary angioplasty and stenting. Blood samples were determined total cholesterol, triglycerides, cholesterol, low density lipoprotein, high density lipoprotein cholesterol, lipoprotein(a), apoprotein A-1, apoprotein B-100. Revealed that the majority of patients the initial values of total cholesterol and low density lipoprotein cholesterol were significantly higher than the target. Increasing the ratio of АpoB-100/АpoA-1 had more than 75% of patients, which is a good indicator of atherogenic shift and progression of atherosclerosis. About 25% of patients had hyperlipoproteinemia(a) exceeding 500 mg/l. Conclusion. High values of low density lipoprotein cholesterol and lipoprotein(a) indicate the inadequacy of the basic lipid-lowering therapy in patients referred for coronary revascularization, and require more aggressive treatment. Otherwise, they contribute to the clinical manifestation atherosclerosis and worse outcomes after coronary stenting.