Assessment of tolerability of cloprostenol-based medicinal product by cattle

The study of the tolerability of the drug to target animal species when repeatedly administered at therapeutic and increased doses is necessary to identify a combination of functional and morphological disorders that appear in the animal after prolonged use of the test drug and in case of its overdose. Long-term intramuscular administration of Regostenol in a therapeutic and increased dose does not have a pronounced pathological effect on the cows. During the experiment, the case of animals and manifestations of clinical signs of intoxication (depression, vomiting, salivation, diarrhea, etc.) were not noted. The animals were active and well-fed. The weight of cows in the test groups did not differ significantly from the animals that were kept in the control group. It has been found that the preparation at the specified doses, duration and method of use does not adversely affect the body of cows and is well tolerated by animals.