Assessment of radio protective and adaptgenic actions of the experimental preparation

In the course of the research, the radioprotective and adaptogenic effects of the new feed additive were determined in experiments on white mice and white rats. It was found that the inclusion of the studied feed additive in the diet of mice after irradiation provided an increase in the survival rate of animals irradiated with a lethal dose by 50% compared to the control. Feeding the mice with the drug followed by irradiation with a lethal dose increased the survival rate by 42 %. In a similar experiment on white rats, the survival rate of the experimental animals was higher than the control values by 58 and 50 %, respectively. When assessing the adaptogenic effect of the drug, it was found that 12-hour immobilization of rats led to significant changes in the prooxidant-antioxidant defense system. Preliminary feeding of the studied feed additive had a protective effect, which was manifested in a lower content of malondialdehyde in the blood serum of experimental animals, compared with control animals, by 28.0 %, an increased content of catalase by 11.1 %, superoxide dismutase by 43.9 %, reduced glutathione - by 17.6 %. Thus, the investigated drug showed a well-pronounced radioprotective and adaptogenic effect.