Unfavorable clinic course of ulcerative colitis: risk assessment with determining gene polymorphism of tumor necrosis factor alpha

The research goal was to assess functional significance that belonged to TNF-α gene polymorphism in the region -308G/A (rs1800629) in ulcerative colitis development. The authors examined 70 patients with ulcerative colitis when the disease was in its active phase and 50 healthy donors. They focused on TNF-α concentration in blood serum and TNF-α gene polymorphism in the region -308G/А. It was detected that TNF-α level was authentically higher in patients who suffered from grave ulcerative colitis and had high endoscopic activity than in people with low endoscopic activity and milder forms of the disease. It allows to apply these tests as additional non-invasive markers to assess apparent damages done to the mucous tunic in the large intestine in a patient suffering from ulcerative colitis. Frequency of allele variations in TNF-α gene -308G/A (rs1800629) was assessed; the assessment revealed that unfavorable homozygote AA significantly more frequently occurred in patients with ulcerative colitis than in donors...