Assessment of the effect of liposomal forms of xymedon and mexidol® on the therapeutic effect of liposomal antineoplastic drugs in the experiment

Our aim is the assessment of effect of liposomal forms of Xymedon and Mexidol on antitumor and antimetastatic efficiency of liposomal combination «doxorubicin/cyclophosphamide» in experimental rats with Walker-256 carcinoma. Material and methods. Experiments were carried out on 116 Wistar female rats of weight 170-270 gm. «Doxorubicin/cyclophosphamide» combination at doses of 4/45 mg/kg, respectively, was administered as a free and liposomal forms intravenously on day 11th day of the experiment. Free and liposomal forms of Xymedon (50 and 100 mg/kg) and Mexidol (25 and 50 mg/kg) were administered intravenously during 5 days starting with day 11 of the experiment. Results. Liposomal form of Xymedon and Mexidol in the studied doses doesn't affect the growth dynamics and mass of primary tumor and doesn't prevent its metastasis suppression at the use of liposomal combination «doxorubicin/cyclophosphamide» in rats with Walker-256 carcinoma. The disappearance of large lung metastases (more than 1 mm in diameter) and predominance of small lung metastases (less than 1 mm in diameter) were observed at the combined use of liposomal Xymedon and Mexidol in the studied doses with liposomal cytostatics. Conclusion. The use of liposomal Xymedon and Mexidol together with chemotherapy by «doxorubicin/cyclophosphamide» liposomal combination doesn't reduce the therapeutic efficiency of these cytostatics and is manifested by the absence of significant changes of slowing down the growth of the primary tumor and its metastasis in rats with Walker-256 carcinoma.