Determinations of tumor necrosis factor alpha, inkleukin-4 and interleukin-6 in a cystose liquid of the epididymis

Introduction. One of the actual problems of modern urology and andrology is the study of the diagnostic significance of cystic formations of the epididymis. However, there are singal indications in the literature on the study of the composition of the contents of the cysts of the epididymis, and at the same time, due attention was not paid to the assessment of the inflammatory factor. Purpose of the work: determination of tumor necrosis factor alpha, interleukin-6 and interleukin-4 in the contents of the cysts of the epididymis. Materials and methods. In the scientific work, the analysis of the results of the examination of 116 men who applied to the Republican Scientific center of urology at the National hospital of the Ministry of Health of the Kyrgyz republic for epididymal cyst. The circulation period falls on 2017-2020. The average age of the surveyed men is 33 years ± 5 years. On ultrasound examination, the average size of the cysts of the epididymis was 30 ± 0.5 mm. In 54 (46.5%) patients, the process was localized on the right, in 62 (52.4%) - on the left, on both sides in 30 (25.8%) patients. The levels of interleukin-6, interleukin-4 and tumor necrosis factor alpha were determined in the cystic fluid. The fluid was obtained by surgical excision of the cysts; it was examined by immunometric analysis using mono and polyclonal antibodies. Results. The result of the research carried out is characterized by an increase the level of cytokines like tumor necrosis factor alpha, interleukin 4, interleukin 6 in all examined patients, which indicates the presence of an aseptic inflammatory process in the cystic fluid of the epididymis and the need for appropriate anti-inflammatory therapy. Conclusion. According to our scientific work, all studied patients showed an increase the level of cytokines like tumor necrosis factor alpha, interleukin 4, interleukin 6 in cystic fluid of the epididymis, which indicates that local production of pro- and anti-inflammatory cytokines are involved in the formation of epididymal cysts, as well as spermatocele.