Determination of toxicity parameters of a new probiotic drug

The purpose of the scientific experiment was to study the toxicity of a new probiotic preparation intended for use in dairy farming. Experiments to determine acute toxicity were carried out on linear white rats, and determination of allergenic and irritating effects on the skin and mucous membrane of the eyes was carried out on rabbits. When studying acute toxicity at the maximum permissible doses (from 3000 to 6000 mg/kg), it was not possible to establish the average lethal dose, since the death of laboratory rats was not observed from any of the tested doses. When determining the irritant and allergenic effects, no noticeable damage to the skin and mucous membrane of the eyes was noted. Based on this, it was concluded that the tested new probiotic preparation is not toxic and does not cause irritant or allergic effects.