Научные статьи
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Прикладные науки. Медицина. Технология
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Mедицинские науки
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Гинекология. Акушерство
Определение порогового значения индекса KI-67 для прогнозирования метастатического поражения лимфатических узлов при раке желудка
Автор: Ашимов Э.А., Чичеватов Д.А., Радовский В.В., Колесникова Е.А., Климин С.А., Гамаюнов С.В., Загайнов В.Е., Киселев Н.М.
Журнал: Злокачественные опухоли @malignanttumors
Рубрика: Оригинальные исследования
Статья в выпуске: 1 т.14, 2024 года.
Бесплатный доступ
Поиск биологических маркеров для оценки метастатического поражения лимфатических узлов при раке желудка - одно из ключевых направлений в определении тактики лечения. Роль индекса Ki-67 как маркера клеточной пролиферации при раке желудка остается актуальной. Целью нашего исследования является определение порогового значения индекса Ki-67 при локализованном раке желудка для прогнозирования метастатического поражения лимфатических узлов. Ретроспективный анализ данных 154 больных раком желудка показал независимую и статистически значимую связь глубины инвазии опухоли T (p = 0,002), степени дифференцировки G (p = 0,010), значения индекса Ki-67 (p
Рак желудка, метастатическое поражение лимфатических узлов, пролиферативный индекс ki-67, прогнозирование, предикторы лимфатического поражения
Короткий адрес: https://sciup.org/140305805
IDR: 140305805 | DOI: 10.18027/2224-5057-2024-14-1-21-29
Determination of the KI-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer
The search for biological markers to assess metastatic involvement of the lymph nodes in gastric cancer is one of the key steps in determining treatment tactics. The role of Ki-67 as a marker of cell proliferation in gastric cancer remains relevant. The aim of our study is to determine the Ki-67 threshold value for predicting the lymph nodes metastases. A retrospective analysis of 154 patients with gastric cancer showed an independent and statistically significant relationship between the depth of tumor invasion T (p = 0.002), the differentiation grade G (p = 0.010), the value of the Ki-67 index (p
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