Determination of radioresistance of the vaccine strain B. abortus 82 to gamma radiation

A comparative study of the radioresistance of various strains of Brucella species B. abortus 82 to gamma rays of 60Co was carried out. It has been established that the degree of inactivation of Brucella strains depends on the dose used, the concentration of microbes in the irradiated suspension, and on the presence of protein protection in the composition of the irradiated object. To completely inactivate Brucella, doses of 8.0 kGy must be used. Thus, when producing antibrucellosis radiovaccines, it is necessary to take into account the degree of density of the irradiated vaccine, since the concentration in vaccines ranges from 1 x 109 to 20 x 109 mc/cm3.