Radiotherapy in management of BRCA-positiveovarian cancer
Автор: Gorodnova Tatiana V., Baranov Sergey B., Tyatkov Tanislav A., Shevkunov Lev N., Sokolenko Anna P., Kotiv Christina B., Imyanitov Evgeny N., Berlev Igor V.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Случай из клинической практики
Статья в выпуске: 4 т.16, 2017 года.
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Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks anddemonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successfultreatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinicalresponse to radiotherapy in combination with platinum-based chemotherapy. The progression-free survivalwas 11 months in one case and 8 months in another case.
Ovarian cancer, DNA repair, platinum-based chemotherapy, radiotherapy
Короткий адрес: https://sciup.org/140253991
IDR: 140253991 | DOI: 10.21294/1814-4861-2017-16-4-103-107
