Experience in the treatment of laboratory rats with notohedrosis

The purpose of the study is to compare the acaricidal effectiveness of the drugs Dironet spot-on and Delcid for notoedrosis of laboratory rats (Wistar breed). To evaluate the therapeutic effectiveness of the drugs, two groups of white rats (Wistar breed) of 25 animals each (with approximately the same body weight - 250 g), spontaneously infested with Notoedres musculi mites, were selected. The diagnosis was made based on characteristic symptoms and microscopy results of deep skin scrapings using the vital method. Acarological studies were carried out in the scientific laboratory of the department of the Federal State Budgetary Educational Institution of Higher Education Verkhnevolzhsky State Agrobiotechnological University (Ivanovo) in 2020-2022. In the first experiment, when using Dironet spot-on (on the skin individually, by drop method in a dose of 0.1 ml (three drops per head), twice with an interval of 10 days), the drug showed high effectiveness against ticks (after the first treatment EI = 20 %, EE = 80), and after the second - EI = 0%, EE = 100 %. After the second treatment, no parasites were found in skin scrapings. In the second experiment, when using Delsid (in the form of manual total spraying at a dose of 0.005 % (according to DB), twice with a difference of 10 days), the drug turned out to be less effective than the first. After the first treatment, EI = 40 %, EE = 60 %, after the second - EI = 12 %, EE = 88 %. After the second treatment, mites were found in skin scrapings on 12 % of treated heads. After using acaricides, the animals were observed daily, taking into account their condition, appetite and skin integrity. Microscopic examinations were carried out before and after the use of drugs, as well as every 10 days for two months after the last treatment of animals. Treatment experience indicates that these acaricides are highly effective drugs. They can be used as a means of therapy and prevention for notoedrosis in rats twice with an interval of 10 days.