Characteristics of COVID-19 associated coagulopathy in real clinical practice

Purpose: to perform a comparative analysis of the hemostasis state in patients with a SARS-CoV-2 infection (COVID- 19) hospitalized in the intensive care unit (ICU). Material and Methods. The retrospective analysis of the medical data of patients with COVID-19 (n=105), admitted to ICU in the «COVID hospital», consisted of the following: complete blood count test; screening global clotting tests routinely performed at admission (activated partial thromboplastin time (APTT), prothrombin index, international normalized index, fibrinogen). Results. We detected sex differences in COVID-19 patients referring hemoglobin level (lower in women, p<0.05) and thrombocytopenia rates (more often in men, p=0.032). There were moderately strong negative correlations between the duration of hospitalization and the leukocytes count at admission (R=0.410; p=0.037), platelet count at admission (R=0.402; p=0.046). In COVID-19 patients we detected increased fibrinogen with a normal or slightly lower platelet count, and normal or slightly increased prothrombin time and APTT. Conclusion. The major coagulation parameters associated with COVID-19 are increased fibrinogen with a normal or slightly lower platelet count, and normal or slightly increased prothrombin time and APTT. COVID-19 associated coagulopathy is characterized by sex differences, which partly determines the specifics of the clinical course of the disease in men and women patients.