Some features of platelet functional activity and endothelial antiaggregatory activity in circumstances when blood-saving techniques are used in cardiac patients with coronary heart disease

The article focuses on a change of platelet hemostasis and antiaggregatory activity of vascular walls during preoperative use of adaptative hypoxia therapy in combination with nutritive treatment in 16 coronary heart disease (CHD) patients with protein-calorie deficiency and a low level of hemoglobin. The study results demonstrate an increase in platelet activity and a decrease in antiaggregatory activity of vascular walls in CHD patients. On completing complex therapy it was found out that the indicator of spontaneous platelet aggregation and the degree of ADP-induced aggregation as compared to those observed before therapy were lower by 1.5 and 1.2 times respectively. When comparing these indicators with similar profiles in healthy donors, no statistically significant differences were found. The measure of antiaggregatory activity of vascular walls subjected to complex therapy exceeded that observed before therapy by 1.5 times. Resetting the above parameters is one of the causes leading to reduction of complications in the hemostatic system and, consequently, to a lesser number of donor blood preparations used perioperatively in CHD patients.