Features of microcirculatory disorders in patients with chronic heart failure and concomitant type 2 diabetes mellitus

In patients with chronic heart failure (CHF) and type 2 diabetes mellitus (T2DM), a crucial role in the pathogenesis of the damage of target organs is assigned to microcirculatory disturbances. The study set out to explore the features of microcirculation in patients with CHF and T2DM by means of laser Doppler flowmetry. The study demonstrated a greater proportion of the spastic type of microcirculation in patients with CHF and T2DM as compared with the group of patients with CHF alone, where the hyperemic type prevailed. Higher indicators of perfusion in peripheral tissues were observed in patients with chronic heart failure alone. When assessing the contribution of various components to the development of a certain type of microcirculation, we found that the neurogenic component in patients suffering from CHF and diabetes mellitus type 2 was predominant. In patients with CHF without concomitant diabetes mellitus, the myogenic component and, to a lesser degree, endothelial component prevailed.