Somatic mutation profiling and functioning of intracellular signaling pathways at various stages of bladder cancer and their significance for targeted therapy

Introduction. Bladder cancer (BC) represents one of the most frequent disease in the structure of morbidity and mortality among malignant neoplasms in human. At the moment, there is a large amount of experimental data about the molecular genetic alterations those occurring in carcinogenesis of BC, but only a few of them are considered as potential predictors of the response to therapy, suitable for using in clinical practice. Many studies underlying BC is a genetically heterogeneous disease. Correlation of various molecular genetic subtypes with clinical and morphological data could be implemented to possible prediction of the BC prognosis and determination of the most effective personalized treatment options. Purpose of the study. Analysis and summarization of actual studies about molecular genetic changes at the DNA and RNA sequences, and their prognostic significance for patients with BC. Materials and methods. We used data about genetic alterations in BC and diagnostic test systems published in the PubMed, Elibrary...