Peculiarities of the inotropic function of the heart of mature rats at adreno stimulators

For the first time, studies were carried out to study the peculiarities of the reaction of the stroke volume of blood in laboratory animals subjected to different modes of locomotor activity with the introduction of β, α1 and α2-adrenostimulants. To study the role of different subtypes of AR and MChR in the regulation of the pumping function of the heart of animals subjected to different modes of locomotor activity, aminophylline (β), meditin (α2), phenylephrine (α1) were administered. Muscle training of the animals was carried out by daily swimming increasing in time and increasing in intensity. Restriction of physical activity, i.e. hypokinesia for laboratory animals was created by keeping them in special pencil cases. To determine the stroke volume of blood, the method of tetrapolar chest rheography was used. It has been established that in animal’s subject to the mode of enhanced motor activity, the SVC response to the administration of β and α1 -adreno stimulants remains at a high level. It was revealed that in animal’s subject to the mode of limited motor activity, there is a significant decrease in the SVR response to the introduction of β, α1 and α2-adrenostimulants. The hypokinesia mode keeps this response low.