Peculiarities of hemostasis system in pregnant women with hyperandrogenism

An examination of 92 pregnant women in the age of 18-35 years old was held on the 28-30 weeks of pregnancy. 1 group consisted of 52 woman with hyperandrogenism (HA), 2 group - 40 women with physiological pregnancy. During the study of aggregative thrombocyte ability using aggregation inductor (adrenaline, collagen, ADP) on aggregometer "Biola LA 230 2", we revealed plausible increase of thrombocyte functional activity in 1 group patients with HA in compare with control group. This increase was confirmed by thromboelastogram indicators and combined with the decrease of antithrombotic potential of vessels endothelium, which in its turn was confirmed by increase of Willebrand factor level in blood plasma. The study of hemostasis system revealed increase in coagulative blood potential during pregnancy with HA, and modifications of rheological and coagulative blood properties of mothers are among key factors of placental insufficiency development.