Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report

Introduction. Cytotoxic corpus callosum syndrome (CLOCC syndrome) is a rare neurological pathology, the pathogenesis of which has not been fully studied. The CLOCC syndrome, which develops in cancer patients, is a serious concomitant pathology that complicates anti-cancer treatment. Description of the clinical case. A 34 year-old female patient was admitted to the A. F. Tsyba MRRC in August 2023 with a diagnosis of stage IV plasmoblastic lymphoma established at her place of residence. Taking into account the severity of the patient’s disease, EPOCH chemotherapy with intrathecal administration of cytostatics was immediately initiated to prevent neuroleukemia. Infectious complications (febrile neutropenia and enterocolitis) that developed during therapy caused neurological disorders, which together with MRI findings, were assessed as CLOCC syndrome. These changes regressed over several days during desmopressin treatment and massive dehydration therapy with crystalloid and glucose solutions. Histological re-examination of the first biopsy specimen and immunohistochemical studies revealed B-lymphoblastic lymphoma, which led to a correction of the further therapy plan. Conclusion. The cause of the development of CLOCC syndrome in this patient can be assumed to be a combination of the damaging effects of cytostatics on brain tissue and electrolyte imbalance.