Peculiarities of toxic effects produced by diisononyl phthalate and regulation over it in polymer materials and medical products

We chose diisononyl phthalate as our experimental research object; this compound is an isononyl ester of phthalic acid based on n-butene (CAS No. 28553-12-0). Our research goal was to establish peculiarities and regularities related to toxic effects produced by diisononyl phthalate on experimental animals’ bodies and give scientific substantiation for fixing its permissible quantities that could migrate from polymer materials and medical products. We accomplished our research applying a set of toxicological, physiological, hematologic, biochemical, immunologic, cytogenetic, morphological, organoleptic, sanitary-chemical, and statistical techniques. We were the first to establish peculiarities of toxic impacts exerted by diisononyl phthalate after intragastric introduction into white rates. Those impacts were dose-dependent toxic effects produced both on a whole body and specific organs and systems with typical disorders in functional and morphological parameters, cell differentiation, and an increase in number of cells with changes in their genetic apparatus...