Acute toxicity and irritant effect of the new drug «Azomethine»

We studied the acute toxicity of the drug «Azomethine» in white mice at doses of 400 mg/kg, 600 mg/kg, 800 mg/kg, 1000 mg/kg, 3000 mg/kg and 5000 mg/kg, as well as the irritant effect on the mucous membranes of rabbit’s solutions in concentrations 0.1 %, 0.3 %, 0.5 %, 0.7 % and 1 %. It was established that with intragastric administration of this compound, the maximum dose of the administered drug was 5000 mg/kg and it belongs to the IV class of danger. The study of the irritant effect on rabbits showed that the solutions of the new compound in 0.1-0.5 % concentrations during the study period do not have a negative impact on the mucous membranes of the eyes.