Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials
Автор: Bockeria Leo A., Agafonov Andrey V., Kiknadze Gennady I, Kuznetsov Victor O., Krestinitch Ivan M., Zhorzholiani Shota T, Sokalskaya Nadezhda O., Gorodkov Alexander Y.
Журнал: Cardiometry @cardiometry
Рубрика: Original research
Статья в выпуске: 4, 2014 года.
Бесплатный доступ
Aims A shortcoming common to all existing designs of mechanical cardiac valve prostheses is an increased trombogenicity caused, among other factors, by the lack of hydrodynamic compatibility between the luminal part of the prosthesis and the patterned blood flow. The aim of the study is to design and test our new mechanical aortic valve prosthesis to exclude life-long anticoagulation treatment. Materials and methods Standard hydrodynamic tests of the new prosthetic valve have been carried out for comparing with the other existing valve designs. A new method for the heart valve prosthesis testing in a tornado-like flow has been developed. The valve function has been verified in a swine excluding the anticoagulation treatment during the period of time exceeding six months. Results The significant advantage of the new prosthesis in the standard hydrodynamic tests has been demonstrated. The tests in the tornado-like flow have shown that only this prosthesis allows maintaining the pattern, the head and flow rate characteristics of the tornado-like jet...
Mechanical aortic valve prosthesis, tornado-like vortex flow, heart flow rate
Короткий адрес: https://sciup.org/148308778
IDR: 148308778 | DOI: 10.12710/cardiometry.2014.4.3145
Список литературы Our new tornado-compatible aortic valve prosthesis: notable results of hydrodynamic testing and experimental trials
- Ahn H, Granfeldt H, Hübbert L, Peterzén B. Long-term left ventricular support in patients with a mechanical aortic valve. Scandinavian Cardiovascular Journal. August 2013;47(4):236-239.
- McKenzie DB., Wong K, Edwards T. The management of patients with mechanical heart valves and intracerebral haemorrhage. British Journal of Cardiology. May 2008;15(3):145-148.
- Bockeria LA, Kiknadze GI, Gachechiladze IA, Gabidullina RF, Makarenko VN, Gorodkov AY. Analysis of Structure of Intraventricular Blood Flow based on studies of architectonics of trabecular layer in left ventricle. Cardiometry. 2013;3:5-30.
- Kiknadze GI, Krasnov YK. Evolution of a Spout-Like Flow of a Viscous Fluid. Sov. Phys. Dokl. 1986;31(10):799-801.
- Bockeria LA, Kiknadze GI, Agafonov AV, Gachechiladze IA, Gorodkov AY. Application of tornado-flow fundamental hydrodynamic theory to the study of blood flow in the heart and main vessels -Design of new implantable and accessory devices for cardiovascular surgery (Conference Paper). ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). 2012;2:93-98.
- Brown CH, Leverett LB, Lewis CW, Alfrey CP, Hellums JD. Morphological, biochemical, and functional changes in human platelets subjected to shear stress. J.Lab. Clin. Med. 1975; 86(3):462-471
- Bockeria LA, Bockeria OL, Fadeev AA, Soboleva NN, Agafonov AV, Melnikov AP, Kuznetsov VO, Nikolaev DA, Mahachev OA, Melnikov DA. First experience in application of the three-leaflet cardiac valve prosthesis CorBeat in a patient with mitral valve failure and permanent atrial fibrillation. Annals of surgery. 2008;2:25-31.
- Rosenberger MR, Favilla PC, Alterach MÁ, Amerio ON, Schvezov CE. Modelizacion, Diseño y Construccion de un Prototipo de Protesis de Valvula Cardiaca. Revista CENIC Ciencias Biológicas.2005;36.
- Ivanov VA, Kevorkova RA, Samkov AV, Podchasov DA. New Generation of Artificial Mechanical Heart Valves: Tri-Leaflet Heart Valve TRICARDICS. Mid-term Results for Prosthesis. Bulletin of scientific and engineering development. 2013;8(72):12-21. [in Russian].
- Bockeria LA, Kiknadze GI, Gorodkov AY, Nikolaev DA, Fadeev AA. Physical modeling of the swirling flow in prosthesis trials in cardiovascular surgery. Bulletin of Bakoulev CCVS for Cardiovascular Surgery. 2008;9(S3):4.
- Butchart EG, De Caterina R. Antithrombotic Management in Patients with Prosthetic Valves. Therapeutic Advances in Thrombosis. 3 October 2012;246-271.
- Van Nooten GJ, Caes F, François K, Van Bellleghem Y, Bové T, Vandenplas G, Taeymans Y. Twenty years' single-center experience with mechanical heart valves: A critical review of anticoagulation policy. Journal of Heart Valve Disease. January 2012;21(1):88-98.
- Charokopos N, Antonitsis P, Artemiou P, Rouska E, Foroulis C, Papakonstantinou C. Acute mechanical prosthetic valve thrombosis after initiating oral anticoagulation therapy. Is bridging anticoagulation with heparin required? Interactive Cardiovascular and Thoracic Surgery. October 2009;9(4):685-687.
- Vaughan P, Waterworth PD. An audit of anticoagulation practice among UK cardiothoracic consultant surgeons following valve replacement/repair. Journal of Heart Valve Disease. September 2005;14(5):576-582.
- Starr A, Fessler CL, Grunkemeier G, He GW. Heart valve replacement surgery: Past, present and future. Clinical and Experimental Pharmacology and Physiology. 2002;29(8):735-738.
- Murabayashi S, Nose Y. Biocompatibility: Bioengineering aspects. Bio-Medical Materials and Engineering. 2013;23(1-2):129-142.
