The cytokines status parameters in multiple sclerosis patients with comorbid depressive disorder

Introduction. The presence of some common immunological pathogenesis mechanisms in multiple sclerosis and depression suggests the possibility of comorbid depressive disorder formation in multiple sclerosis patients, which significantly worsens their quality of life and patient's compliance. In this regard, the depressive pathology diagnosis in people suffering from multiple sclerosis acquires important scientific and practical value. The aim of the study was the cytokine status peculiarities identification in multiple sclerosis patients with comorbid recurrent depressive disorder (F33). Methods. Determination of cytokine production in the patient's blood mononuclear cells culture supernatants was carried out by the method of enzyme-linked immunosorbent assay. The depressive disorders symptoms severity was determined according to the M. Hamilton and A.T. Beck depression scales, as well as during the clinical interview. Results. A higher production of IL-6 was noted in multiple sclerosis patients with mild recurrent depressive disorder (F33...