Pathogenetic significance of changes of colonic microflora in psoriasis

The article presents the results of a study of the microflora of the large intestine in patients with psoriasis. Installed disbiotic shifts in the composition of the colonic microbiota in the patients examined, revealed the relationship severity of psoriatic disease and severity of intestinal dysbiosis.The aim of the study was to examine the state of the colonic microbiota in patients with psoriasis and its composition depending on the type and severity of the disease.Materials and methods. We carry out an objective examination of patients. Estimation of the severity of psoriasis was performed by a conventional index coverage and severity of psoriasis - PASI. The study of intestinal microflora in patients with psoriasis and control group was carried out according to the order of Ministry of Health of Russia. The cultures grown on nutrient media were a group, genera and species identification (Staphylococcus, Escherichia).The results showed that all patients skin process was widespread, with PASI assessment from 38,8 to72 points. Surveyed patients have had the following forms of psoriasis: psoriasis vulgaris (PsV) - 73,55 %, psoriatic arthritis (PsAr) - 26,45 %. In all cases, psoriatic arthritis was accompanied by the presence of cutaneous manifestations of widespread psoriatic process. In the study of colon microflora changes, depending on the forms of psoriasis, there was a slight inhibition of obligate organisms appears to reduce contamination of the large intestine. The findings suggest that the presence of deeper dysbiotic violations in the large intestine in patients with severe psoriasis in conjunction with arthritis, manifested in inhibition of the growth of normal microflora and opportunistic, and even pathogens. The greatest changes in composition of the microflora were observed at the experience of psoriasis disease for over 20 years.Conclusions. In 86 % of surveyed patients with psoriasis found the phenomenon of dysbiosis in the large intestine. Disbiotic compounded shifts depending on the severity of the skin and the process was more pronounced in patients with psoriatic arthritis in combination.