Pathogenetic significance of cytokine imbalance in postextraction alveolitis development of extraction tooth socket (review)

The review presents data on the stages of wound healing and extracted tooth socket in acute and chronic inflammatory processes, cytokine system effect on inflammation character. Objective: to present pathogenic role of cytokine imbalance in extracted tooth socket alveolitis development. Data analysis was carried out on the following Internet resources: eLibrary, Cyberleninka, disserCat, PubMed, ResearchGate, data base of Journal «Medical Immunology» (48 references from 2000 until 2021 years). Based on the analysis, it was concluded that the pathophysiological mechanisms of alveolitis development, based on cellular and molecular-biochemical reactions, haven't been studied enough, the data on this issue are fragmentary and contradictory, there are no laboratory criteria for early detection of disease, warning of initial stage of development of an inflammatory complication and allowing to create its preventive pathogenetic treatment.