Pathomorphological studies of the internal organs of laboratory rats when studying the chronic toxicity of the feed additive kobamethin

The aim of the research was to study the effect of the feed additive kobamethine on organs and tissues of laboratory animals with prolonged use. According to the research results, there is a significant difference in the liver mass coefficient between the animals of the control and experimental groups: in group 1, this indicator was 15.39 % higher than in the control, and in the 2nd experimental group by 25.7 %. There was also a significant difference between the control and the 2nd experimental group in terms of the difference in the mass coefficients of the spleen: in the experimental group, this indicator was lower by 16.4 %. Pathoanatomical and histological studies have shown that the feed additive kobamethine in doses of 153.0 mg/kg 307.0 mg/kg can cause hemodynamic disorders and to varying degrees pronounced dystrophic changes in the internal organs of experimental rats. No pathomorphological changes were found in the control group of animals. The results obtained should be taken into account when compiling a complete picture of the chronic toxic effect of the supplement, taking into account laboratory data from a general blood test and a biochemical profile of blood serum in order to predict possible side effects when choosing doses in clinical trials.