Peculiarities of the course of Lewis lung epidermoid carcinoma in mice infected with mycobacter tuberculosis

Introduction. The potential relationship between pulmonary tuberculosis and lung cancer remains still poorly understood. The aim of our work was to study the features of the course of the tumor process and pulmonary tuberculosis in mice infected with Mycobacterium tuberculosis with transplanted Lewis epidermoid lung carcinoma. Material and methods. The study was carried out on 88 C57BL/6 mice aged two months. In accordance with the purpose of the study, the following groups of animals were composed: group 1 - "intact mice" (n=12), group 2 - "the reference H37R infection" (animals infected with the M.tuberculosis H37RV strain) (n=24), group 3 - "the reference tumors” (animals transplanted with Lewis epidermoid lung carcinoma) (n=23), group 4 - “the main test group 1” (animals infected with M.tuberculosis H37RV strain, which were simultaneously transplanted with Lewis epidermoid lung carcinoma) (n=24). Animals were infected by inoculating a suspension of Mycobacteria (1x106 CFU/0.2 ml) into the lateral tail vein. Transplantation of a 10% suspension of the pulverized tumor in a 0.9% solution of sodium chloride was performed intramuscularly into the femur within 2 hours after their infection with the suspension of Mycobacteria.