Tolerate of the drug for veterinary use tulatrin

Mass antibacterial therapy carried out according to therapeutic and preventive schemes is considered to be a highly effective and the most rational measure for controlling infectious diseases in the conditions of large-scale industrial pig breeding. It was found that the long-term intramuscular use of the drug Tulatrin in a therapeutic and three-fold therapeutic dose does not have a pronounced pathological effect on pigs. During the experiment, no animal deaths and manifestations of clinical signs of intoxication (depression, vomiting, salivation, diarrhea, etc.) were noted. The animals were active and ate food well. The live weight of piglets in experimental groups does not significantly differ from the animals that were kept in the control groups. The liver is the most sensitive to the action of tulatromyc in with prolonged intake of the drug in higher doses, which is confirmed by the results of biochemical studies. However, the intrinsic hepatotoxicity associated with the use of high doses, or with prolonged use, is characteristic of all drugs of the macrolide group. It should be noted that in this case, the maximum increase in marker liver enzymes does not exceed 10 % of the upper limit of the norm, so we can say that the liver damage is of a trace nature, since the clinical significance is an increase in liver samples by at least 2 times. Also, the increase in total protein was not fatal and did not affect the change in the clinical status of animals. We did not note the death of animals and the manifestation of clinical signs of intoxication and hepatopathy. Tulatrin is one of the safe medicines, and is characterized by good tolerability. The results obtained confirm the safety of using the drug in the recommended dosage regimen.