Personalized approach to adjuvant chemotherapy in patients with non-small cell lung cancer

Numerous studies have shown that differential expression and/or co-expression of several chemosensitivity genes, such as ERCC1, RRM1, TUBB3, TOP2A, and some others, in the tumor tissue are closely associated with chemoresistance and prognosis in cancer patients. Despite the fact that more and more data comes to support the idea on the important role of the presented genes in the assessment of chemosensitivity (CS), at present time there is ample room remaining for further research of the combined estimation of the CS gene expression for a personalized approach to chemotherapy in patients with lung cancer.