Personalized approach to postoperative chemotherapy in the combined modality treatment of non-small cell lung cancer (clinical case)
Автор: Rodionov Evgeny O., Miller Sergey V., Tsyganov Matvey M., Cheremisina Olga V., Tuzikov Sergey A., Litviakov Nikolay V., Frolova Irina G., Velichko Svetlana A., Lukyanenok Pavel I., Polishchuk Tatyana V.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Случай из клинической практики
Статья в выпуске: 3 (75), 2016 года.
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We present a clinical case of non-small cell lung cancer treated with personalized adjuvant chemotherapy. The expression levels of drug resistance genes, such as ABCC5, RRM1, ERCC1, TOP1, TOP2a, TUBB3 and TYMS in tumor tissue from non-small cell lung cancer were used as predictive markers. This case shows the usefulness of determination of the expression of drug resistance genes before and after preoperative chemotherapy, and it is important in terms of determining the individual sensitivity of the tumor to chemotherapy drugs, thus allowing the treatment plan for the individual patient to be tailored.
Combination therapy, lung cancer, an individual approach, drug resistance genes, adjuvant chemotherapy
Короткий адрес: https://sciup.org/14056693
IDR: 14056693 | DOI: 10.21294/1814-4861-2016-15-3-97-101
