Перспективы применения внеклеточных везикул, выделенных из мезенхимных стволовых клеток, в регенеративной урологии

Перспективы применения внеклеточных везикул, выделенных из мезенхимных стволовых клеток, в регенеративной урологии

Автор: Иванова Янина Георгиевна, Муравьев А.Н., Виноградова Т.И., Орлова Н.В., Ремезова А.Н., Горелова А.А., Горбунов А.И., Шумко В.В., Юдинцева Н.М., Нащекина Ю.А., Полякова В.О., Яблонский П.К.

Журнал: Экспериментальная и клиническая урология @ecuro

Рубрика: Экспериментальная урология

Статья в выпуске: 4 т.17, 2024 года.

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Введение. В последние десятилетия в области регенеративной медицины особый интерес вызывают мезенхимные стволовые клетки (МСК) и выделенные из них внеклеточные везикулы (ВВ-МСК). Последние опосредуют паракринное действие МСК, обуславливая противовоспалительные, проангиогенные, имунномодулирующие, противофиброзные эффекты в поврежденных тканях/структурах/органах.

Регенеративная урология, внеклеточные везикулы, мезенхимные стволовые клетки

Короткий адрес: https://sciup.org/142243852

IDR: 142243852   |   DOI: 10.29188/2222-8543-2024-17-4-24-36

Список литературы Перспективы применения внеклеточных везикул, выделенных из мезенхимных стволовых клеток, в регенеративной урологии

  • Jovic D, Yu Y, Wang D, Wang K, Li H, Xu F, Liu C, Liu J, Luo Y. A brief overview of global trends in MSC-based cell therapy. Stem Cell Rev Rep 2022;18:1525-1545. https://doi.org/10.1007/s12015-022-10369-1.
  • Юдинцева Н.М., Шевцов М.А., Хотин М.Г., Виноградова Т.И., Муравьев А.Н., Ремезова А.Н. и др. Применение мезенхимных стволовых клеток и внеклеточных везикул в терапии инфекционных заболеваний. Молекулярная медицина 2022;20(6):16-24. [Yudintceva N.M., Shevtsov M.A., Khotin M.G., Vinogradova T.I., Muraviov A.N., Remezova A.N., Mikhailova N.A. Application of mesenchymal stem cells and extracellular vesicles in infectious treatment. Molekulyarnaya Meditsina = Molecular medicine 2022;20(6):16-24. https://doi.org/10.29296/24999490-2022-06-03. (In Russian)].
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 2008;8(4):315-317. https://doi.org/10.1080/14653240600855905.
  • Сагарадзе Г.Д., Ефименко А.Ю., Макаревич О.А., Басалова Н.А., Нимирицкий П.П., Макаревич П.И., Кирпатовский В.И. и др. Секретом мезенхимных стволовых/ стромальных клеток (МСК) человека как основа для создания новых препаратов и биоматериалов для регенеративной медицины. Гены и клетки 2017;12(3):211-212. [Sagaradze G.D., Efimenko A.Yu., Makarevich O.A., Basalova N.A., Nimiritsky P.P., Makarevich P.I., Kirpatovsky V.I. et al. Secretome of human mesenchymal stem/stromal cells (MSCs) as a basis for creating new drugs and biomaterials for regenerative medicine. Geny i kletki = Genes & Cells 2017;12(3):211-212. (In Russian)].
  • Álvarez-Viejo M.. Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective. World J Stem Cells 2020;12(2):100-109. https://doi.org/10.4252/wjsc.v12.i2.100.
  • Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018;7(1):1-43. https://doi.org/10.1080/20013078.2018.1535750.
  • Jeppesen DK, Zhang Q, Franklin JL, Coffey RJ. Extracellular vesicles and nanoparticles: emerging complexities. Trends Cell Biol 2023;33(8):667-681. https://doi.org/10.1016/j.tcb.2023.01.002.
  • Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol 2019;21(9):9-17. https://doi.org/10.1038/s41556-018-0250-9.
  • Grange C, Tritta S, Tapparo M, Cedrino M, Tetta C, Camussi G, et al. Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy. Sci Rep 2019;9(4468):1-13. https://doi.org/10.1038/s41598-019-41100-9.
  • Caplan H, Olson SD, Kumar A, George M, Prabhakara KS, Wenzel P, et al. Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application. Front Immunol 2019;10(1645). https://doi.org/10.3389/fimmu.2019.01645.
  • Zhou T, Yuan Z, Weng J, Pei D, Du X, He C, et al. Challenges and advances in clinical applications of mesenchymal stromal cells. J Hematol Oncol 2021;14(24). https://doi.org/10.1186/s13045-021-01037-x.
  • Li Z, Liu C, Li S, Li T, Li Y, Wang N, et al. BMSC-Derived exosomes inhibit dexamethasone-induced muscle atrophy via the miR-486-5p/FoxO1 Axis. Front Endocrinol 2021;12(681267):1-10. https://doi.org/10.3389/fendo.2021.681267.
  • Palanisamy CP, Pei J, Alugoju P, Anthikapalli NVA, Jayaraman S, Veeraraghavan VP, et al. New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics 2023;13(12):4138-4165. https://doi.org/10.7150/thno.83066.
  • Jia Y, Qiu S, Xu J, Kang Q, Chai Y. Exosomes secreted by young mesenchymal stem cells promote new bone formation during distraction osteogenesis in older rats. Calcif Tissue Int 2020;106:509-517. https://doi.org/10.1007/s00223-019-00656-4.
  • Liu X, Yang Y, Li Y, Niu X, Zhao B, Wang Y, et al. Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration. Nanoscale 2017;9(13):4430-4438. https://doi.org/10.1039/C7NR00352H.
  • Zhang J, Lu T, Xiao J, Du C, Chen H, Li R, et al. MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration. J Control Release 2023;356:402-415. https://doi.org/10.1016/j.jconrel.2023.02.032.
  • Tang J, Cui X, Zhang Z, Xu Y, Guo J, Soliman BG, et al. Injection-free delivery of MSC-Derived extracellular vesicles for myocardial infarction therapeutics. Adv Healthc Mater 2022;11(5):133-140. https://doi.org/10.1002/adhm.202100312.
  • Figliolini F, Ranghino A, Grange C, Cedrino M, Tapparo M, Cavallari C, et al. Extracellular vesicles from adipose stem cells prevent muscle damage and inflammation in a mouse model of hind limb ischemia: role of Neuregulin-1. Arterioscler Thromb Vasc Biol 2019;40(1):239-254. https://doi.org/10.1161/ATVBAHA.119.313506.
  • Su Y, Guo H, Liu Q. Effects of mesenchymal stromal cell-derived extracellular vesicles in acute respiratory distress syndrome (ARDS): Current understanding and future perspectives. J Leukoc Biol 2021;110(1):27-38. https://doi.org/10.1002/JLB.3MR0321-545RR.
  • Tolomeo AM, Castagliuolo I, Piccoli M, Grassi M, Magarotto F, De Lazzari G, etal. Extracellular vesicles secreted by mesenchymal stromal cells exert opposite effects to their cells of origin in murine sodium dextran sulfate-induced colitis. Front Immunol 2021;12:1-15. https://doi.org/10.3389/fimmu.2021.627605/full.
  • Berger A , Araújo-Filho I , Piffoux M , Nicolás-Boluda A , Grangier A, Boucenna I , et al. Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous postsurgical fistula. Nanoscale 2021;13(1):218-232. https://doi.org/10.1039/D0NR07349K.
  • Casado-Díaz A, Quesada-Gómez JM, Dorado G. Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing. Front Bioeng Biotechnol 2020;8(146):1-19. https://doi.org/10.3389/bioe.2020.00146.
  • Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009;20(5):1053-1067. https://doi.org/10.1681/ASN.2008070798.
  • Zhou Y, Xu H, Xu W, Wang B, Wu H, Tao Y, et al. Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res Ther 2013;4(34):1-13. https://doi.org/10.1186/scrt194.
  • Liu Y, Cui J, Wang H, Hezam K, Zhao X, Huang H, et al. Enhanced therapeutic effects of MSC-derived extracellular vesicles with an injectable collagen matrix for experimental acute kidney injury treatment. Stem Cell Res Ther 2020;11(161):1-12. https://doi.org/10.1186/s13287-020-01668-w.
  • Shen B, Liu J, Zhang F, Wang Y, Qin Y, Zhou Z, et al. CCR2 Positive exosome released by mesenchymal stem cells suppresses macrophage functions and alleviates ischemia/reperfusion-induced renal injury. Stem Cells Int 2016;41(2):119-128. https://doi.org/10.1159/000443413.
  • Rayego-Mateos S, Valdivielso JM. New therapeutic targets in chronic kidney disease progression and renal fibrosis. Expert Opin Ther Targets 2020;24(7):655-670. https://doi.org/10.1080/14728222.2020.1762173.
  • He J, Wang Y, Sun S, Yu M, Wang C, Pei X, et al. Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model. Nephrology 2012;17(5): 493-500. https://doi.org/10.1111/j.1440-1797.2012.01589.x.
  • Kholia S, Herrera Sanchez MB, Cedrino M, Papadimitriou E, Tapparo M, Deregibus MC, et al. Mesenchymal stem cell derived extracellular vesicles ameliorate kidney injury in aristolochic acid nephropathy. Front Cell Dev Biol 2020;8(188):1-17. https://doi.org/10.3389/fcell.2020.00188.
  • Lee K, Nelson CM. New insights into the regulation of epithelialmesenchymal transition and tissue fibrosis. Int Rev Cell Mol Biol 2012;294:171-221. https://doi.org/10.1016/B978-0-12-394305-7.00004-5.
  • Hills CE, Squires PE. The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy. Cytokine Growth Factor Rev 2011;22(3):131-139. https://doi.org/10.1016/j.cytogfr.2011.06.002.
  • Meng XM, Tang PM, Li J, Lan HY. TGF-β/Smad signaling in renal fibrosis. Front Physiol 2015;6(82):1-8. https://doi.org/10.3389/fphys.2015.00082.
  • He J, Wang Y, Lu X, Zhu B, Pei X, Wu J, Zhao W. Micro-vesicles derived from bone marrow stem cells protect the kidney both in vivo and in vitro by microRNA-dependent repairing. Nephrology (Carlton) 2015;20(9):591-600. https://doi.org/10.1111/nep.12490.
  • Jacobs ME, de Kemp VF, Albersen M, de Kort LMO, de Graaf P. The use of local therapy in preventing urethral strictures: a systematic review. PLoS One 2021;16(10):1-14. https://doi.org/10.1371/journal.pone.0258256.
  • Shi Z, Wang Q, Jiang D.The preventative effect of bone marrow-derived mesenchymal stem cell exosomes on urethral stricture in rats. Transl Androl Urol 2020;9(5):2071-2081. https://doi.org/10.21037/tau-20-833.
  • Luo J, Zhao S, Wang J, Luo L, Li E, Zhu Z, et al. Bone marrow mesenchymal stem cells reduce ureteral stricture formation in a rat model via the paracrine effect of extracellular vesicles. J Cell Mol Med 2018;22(9):4021-4554. https://doi.org/10.1111/jcmm.13744.
  • Dissaranan C, Cruz MA, Kiedrowski MJ, Balog BM, Gill BC, Penn MS, et al. Rat mesenchymal stem cell secretome promotes elastogenesis and facilitates recovery from simulated childbirth injury. Cell Transplant 2014;23(11):1395-1406. https://doi.org/10.3727/096368913X670921.
  • Deng K, Lin DL, Hanzlicek B, Balog B, Penn MS, Kiedrowski MJ, et al. Mesenchymal stem cells and their secretome partially restore nerve and urethral function in a dual muscle and nerve injury stress urinary incontinence model. Am J Physiol Renal Physiol 2015;308(2):92-100. https://doi.org/10.1152/ajprenal.00510.2014.
  • Ni J, Li H, Zhou Y, Gu B, Xu Y, Fu Q, et al. Therapeutic potential of human adiposederived stem cell exosomes in stress urinary incontinence – an in Vitro and in Vivo study. Cell Physiol Biochem 2018;48(4):1710-1722. https://doi.org/10.1159/000492298.
  • Helissey C, Guitard N, Théry H, Goulinet S, Mauduit P, Girleanu M, et al. Two new potential therapeutic approaches in radiation cystitis derived from mesenchymal stem cells: extracellular vesicles and conditioned medium. Biology 2022;11(980):1-20. https://doi.org/10.3390/biology11070980.
  • Qiu X, Zhang S, Zhao X, Fu K, Guo H.The therapeutic effect of adipose-derived mesenchymal stem cells for radiation-induced bladder injury. Stem Cells Int 2016;2016(1):1-8. https://doi.org/10.1155/2016/3679047.
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