Phenotypic composition of tumor cells and their role in the process of metastasis when developing a PDX model of breast cancer

To study the mechanisms of metastasis, one of the effective tools is mouse models using primary patient tumors (Patient-Derived Xenograft, PDX). The phenomenon of changes in the cell phenotype in response to the dynamic conditions of the tumor microenvironment is one of the key processes forming the basis for metastasis. The aim hereof is to investigate the phenotypic composition of tumor cells during the process of metastasis using an example of the PDX models of breast cancer.