Placebo-controlled tests in pediatrics

The article discusses the use of medication for children who have not been sufficiently studied, and, in fact, being considered as small replicas of adults, it was considered sufficient to adjust the dosage of the drug approved for adults. To establish the efficacy of a new drug, randomized clinical trials (RCTs) often include a placebo control group that carries the burden of additional, and to some extent, underestimated, ethical issues with regard to trials in adults.