Плейотропные эффекты левосимендана на сердце и другие органы

Плейотропные эффекты левосимендана на сердце и другие органы

Автор: Ломиворотов В.В., Бобошко Владимир Александрович

Журнал: Патология кровообращения и кардиохирургия @journal-meshalkin

Рубрика: Обзоры

Статья в выпуске: 2 т.21, 2017 года.

Бесплатный доступ

Девосимендан - негликозидное кардиотоническое лекарственное средство, обладающее вазодилатирующими свойствами. К основным механизмам действия препарата относят увеличение чувствительности сократительных белков кардиомиоцитов к кальцию и способность открывать аденозинтрифосфат-зависимые калиевые каналы в гладких мышцах сосудистой стенки. В соответствии с рекомендациями Европейского общества кардиологов, показанием к использованию левосимендана является лечение острой декомпенсации тяжелой хронической сердечной недостаточности. С момента первого применения препарата (более 15 лет назад) обнаружены дополнительные плейотропные эффекты, которые не только влияют на состояние миокарда (при ишемии и ремоделировании), но и потенцируют органопротективные процессы за пределами сердечно-сосудистой системы. В ходе экспериментальных и клинических исследований выявлены механизмы, положительное влияющие на функцию легких, почек, печени, органов желудочно-кишечного тракта, центральной нервной системы, а также на процессы воспаления и сепсиса. В обзоре обобщены существующие исследования и доказательства плейотропных эффектов левосимендана, а также показаны потенциальные новые области его клинического применения.

Еще

Левосимендан, плейотропные эффекты, кардиотонические препараты, сердечная недостаточность, инфаркт миокарда, кардиогенный шок, кардиопротекция, органопротекция

Короткий адрес: https://sciup.org/142140793

IDR: 142140793   |   DOI: 10.21688-1681-3472-2017-2-14-28

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