Indicators of systemic inflammation in patients with coronary artery disease and respiratory pathology

Aim. To estimate the severity of systemic inflammation in subjects with coronary artery disease (CAD) coexisting with respiratory system diseases. Subjects and methods. Subjects with CAD were divided into three groups depending on the presence of respiratory system diseases and ventilation disorders. Respiratory pulmonary function tests included spirometry, body plethysmography, and estimation of diffusing capacity (Dlco). The assessment of laboratory markers of nonspecific inflammation in blood serum included determination of the levels of interleukin-12, interleukin-1β, tumor necrosis factor-α, matrix metalloproteinase-9, and C-reactive protein. Results. Subjects who had no anamnestic and instrumental signs of respiratory system damage revealed the lowest concentrations of all the analyzed inflammatory indicators; maximum concentrations of inflammatory markers in blood serum were observed in subjects who had symptoms of obstructive disorders. Severity of nonspecific inflammation correlated with the degree of heart failure, speed and volume parameters of respiration (FEV1, FVC, TLC, RV), as well as with Dlco. Conclusion. The coexistence of CAD and lung diseases both with obstructive abnormalities and without ventilation disorders caused higher levels of systemic inflammatory markers.