Gene polymorphisms of the renin-angiotensine system in children with malformations of urinary system

Purpose. The prospects of studying the genetic factors of identification of patients at high risk of malignant course of chronic kidney disease (CKD) in children is obvious. The aim of our study was a comparative assessment of the genetic predisposition to malignant CKD in children with congenital urinary tract abnormalities (VAMP) and nephritis based on the study of gene polymorphism of the renin-angiotensin system. Methods. The study included 95 children. Depending on the cause of CKD, patients were divided into two groups -comparison group (n=52), children with glomerulonephritis. Main group (n=43) patients whose development of CKD was associated with VAMP. A definition of the frequencies of alleles and genotypes of polymorphic loci of renin-an-giotenzinovyh system (angiotensin receptor 1 (AGTR1, rs5186 (1166A/C)), angiotensin-converting enzyme (ACE, (Ins-Del)), angiotensin II receptor of the second type (AGTR2, -1332A/G, rs1403543 (G1675A)), angioten-zinoguena (AGT, rs4762 (Thr174Met), rs699 (M235T))...