Polymorphic variants of the renin-angiotensin-aldosterone system genes associated with the risk of hypertension development (review)

Arterial hypertension refers to multifactorial pathology. Both environmental factors and genetic risk factors contribute to its development. One of the promising areas for the early diagnosis and prevention of hypertension may be the identification of genes whose mutations predispose to its development. The review analyzes the works published for the period 2010-2020 (38 scientific papers), devoted to the molecular genetic basis of the development of arterial hypertension and identifying the possible role of polymorphism of the renin-angiotensin-aldosterone system genes in the genesis of hypertension. The search for sources was carried out in the databases PubMed®, Scopus®, EBSCOhost, Medline, eLIBRARYRU.