Ex vivo human platelet production

Cell technologies are on the upswing around the world. And recent successes in the production of human platelets from stem cells are opening the prospect for development of the technology for ex vivo platelet production for clinic. Platelet transfusion saves millions of lives around the world and the needs for donor platelets are growing by the day. Despite all the developed strategies yet, the desired amount of platelets has not yet been achieved. In the present paper a review of recent studies of the strategies in this field is presented. The challenges of the developed approaches are discussed as well as the ways to increase the efficiency of ex vivo human platelet production. In spite of forthcoming efforts great progress in ex vivo human platelet production for clinic has already been gained.