The biopotential of trans-cinnamic acid

Trans-cinnamic acid (TKR-k) is a natural organic compound that is used in the synthesis of various chemical and pharmaceutical preparations, biologically active additives (dietary supplements). It has high biological activity, including antioxidant and antibacterial abilities. The aim of the work was to study the biopotential and biosafety of trans-cinnamic acid isolated from the cellular biomass of the Baikal skullcap (Scutellaria baicalensis) using model rodent objects for its further application in the development of dietary supplements with geroprotective activity. The object of the study was TKR-k, isolated in previously conducted studies by the authors from the biomass of the Baikal skullcap (Scutellaria baicalensis). For in vivo studies, rodents were used as model objects: female rats (Rattus sp.) Sprague Dawley, male rats Rattus sp., male rats Wistar, male mice Mus musculus, female mice (Mus musculus) stock CD-1. As a result, it was established that TKR-k did not have mutagenic properties, and when administered a dose of 50.0 mg/kg, it exhibited antimutagenic potential; did not exhibit cytotoxicity in the concentration range of 2.1-33.3 μg/ml. TKR-k did not have hypocholesterolemic activity and hepatotoxicity. However, TKR-k exhibited a pro-inflammatory effect in acute inflammation (caused by λ-carrageenan) - it statistically significantly reduced the mass of granulation tissue by 20 %, but had no effect on the exudative reaction in proliferative inflammation caused by implantation of cotton swabs under the skin. I chew on rats. It has been established that TKR-k in vivo on rodents is a bio-safe substance exhibiting antimutagenic potential that does not stimulate the development of hypocholesterolemic activity and hepatotoxicity, therefore, a promising component of dietary supplements with geroprotective potential.