Late gestosis of pregnant - significance of immunobiochemical disorders

To study the features of immunobiochemical disorders in the pathogenesis of late gestosis of pregnancy, we studied 80 women in the third trimester of pregnancy. 60 women were diagnosed with late gestosis, and 20 pregnant women with physiological course of pregnancy. In women with late gestosis we revealed high concentrations of proinflammatory cytokines IL-1ƒ, IL-6, IL-8, acute phase proteins - lactoferrin and the ratio of proinflammatory / antiinflammatory interleukins. Also we revealed the high level of markers of cell destruction - autoantibodies to antigen native DNA and markers of endothelial dysfunction - vascular endothelial adhesion molecule 1. Thus in the pathogenesis of late pregnancy gestosis significant role is played by integrated development of the destructive inflammatory process and endothelial dysfunction.