Predictors of activity and progression of multiple sclerosis (review)

Modern therapy for multiple sclerosis (MS) is based on a large selection of disease-modifying treatment (DMT). The appointment of DMT is made taking into account the medium- and long-term prospects of their effectiveness. There is a problem of finding predictors of the effectiveness of therapy. The question of determining the risk factors for the onset of reliable MS after the first attack of demyelination remains not fully understood. The analysis of studies published for the period 2006-2020, available for study according to the main scientific bases, is carried out (46 literary sources). Magnetic resonance imaging (MRI) has shown good results in predicting the effectiveness of interferon DMT therapy. MRI as a reliable criterion for the likelihood of transformation into significant multiple sclerosis after the first attack of demyelination. Multimodal evoked potentials (EP) allow assessing degeneration processes with greater sensitivity than MRI. At the moment, only MRI is the most reliable way to assess the progression of the disease and the risks of its phenoconversion. Multimodal evoked potentials and immunological markers allow more sensitive assessment of degeneration. The integrated use of the results of these methods will make it possible to obtain predictors with greater sensitivity and specificity for predicting the course of MS.