Предикторы активности и прогрессии рассеянного склероза (обзор)

Предикторы активности и прогрессии рассеянного склероза (обзор)

Автор: Захаров А.В., Хивинцева Е.В., Повереннова И.Е., Баранова О.М.

Журнал: Саратовский научно-медицинский журнал @ssmj

Рубрика: Нервные болезни

Статья в выпуске: 1 т.17, 2021 года.

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Современная терапия рассеянного склероза (PC) основывается на большом выборе препаратов, изменяющих его течение (ПИТРС), назначение которых производится с учетом среднесрочной и долгосрочной перспективы их эффективности. Существует проблема поиска предикторов эффективности терапии. Остается не полностью изученным вопрос определения факторов риска возникновения достоверного PC после первой атаки демиелинизации. Проведен анализ исследований, опубликованных за период 2006-2020 гг., доступных к изучению по данным основных научных баз (46 литературных источников). Магнитно-резонансная томография (МРТ) продемонстрировала хорошие результаты в отношении прогноза эффективности терапии ПИТРС интерферонового ряда и в качестве надежного критерия вероятности трансформации в достоверный рассеянный склероз после первой атаки демиелинизации. Мультимодальные вызванные потенциалы (ВП) позволяют оценить процессы дегенерации с большей чувствительностью, чем МРТ. На данный момент только МРТ является наиболее надежным способом оценки прогрессии заболевания и рисков его феноконверсии. Мультимо-дальные ВП и иммунологические маркеры более чувствительны к оценке дегенерации. Комплексное использование результатов данных методов дает возможность получить предикторы с большей чувствительностью и специфичностью для прогноза течения PC.

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Рассеянный склероз, магнитно-резонансная томография, иммунология, вызванные потенциалы

Короткий адрес: https://sciup.org/149134991

IDR: 149134991

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