Present-day tendencies in accompanying therapy in cancer treatment: from theory of adaptational reactions to bio-information technologies translation

At present, to develop new, scientifically justified, technologies of an accompanying therapy to improve the oncological situation is a challenge to health care. A therapy to accompany a specific cancer treatment in case of a malignant process in an organism is dictated by the necessity to raise the nonspecific resistance of the organism in cancer patients. In this case, original methodological approaches to initiate the mechanisms of the nonspecific resistance have been developed on the basis of the theory of the adaptational reactions. Within the framework of the above theory, some concepts of relationship between the specific and nonspecific anti-tumor processes have been extensively developed that may be successfully applied to solving tasks of the National Health Care Program. Aim. The aim hereof is to introduce the theoretical basics of the nonspecific adaptation regulation and control by a tumor- bearing organism into practice for an integrated treatment of malignant tumors with the use of the activation therapy technologies. Materials and methods. Our research work has involved clinical data on 1310 patients, who have been diagnosed with cancer of different localization: breast cancer (n = 170), cervical cancer (n = 60), lung cancer (n = 760), bladder cancer (n = 120), brain gliomas of high grade of malignancy and metastatic damage (n = 170) and extended colorectal cancer (n = 30) and who have completed their treatment at the National Medical Research Centre of Oncology of the Ministry of Health of the Russian Federation. Results and Discussion. We have used at different stages of the cancer treatment some technologies of the accompanying therapy, designed and developed on the basis of the approaches and principles of adaptive responding by a human organism. The above line of attack has provided a time- and intensity- scheduled functional loading (some factors of the electromagnetic and pharmacological nature) under control over formation of the desired stable reactions of the anti-stressor type. Following the principles of the activation therapy, the designed programmable regimes of extra actions and exposures have resulted in improvement of immediate outcomes of the treatment of malignant tumors, raise in quality and prolongation of life in our cancer patients.