Применение гиперупругих моделей для описания поведения разных областей овечьего сердца на основе двухосных механических испытаний
Автор: Немавхола Ф., Панделани Т., Нгвангва Г.
Журнал: Российский журнал биомеханики @journal-biomech
Статья в выпуске: 2 (96) т.26, 2022 года.
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Сердечная недостаточность остается одной из самых распространенных причин смерти во всем мире, особенно среди людей старше 60 лет. Чтобы разработать и подобрать подходящие материалы для замены тканей сердца с целью эффективного лечения, необходимо понять биомеханику сердца при нагрузке. В работе исследуется механический отклик пассивного миокарда овцы, полученного из трех разных областей сердца. Так как стоимость модели сердца живого животного высока, а проведение экспериментальных исследований требует прохождения строгой этической экспертизы, авторы оценивают соответствие шести различных гиперупругих моделей по механическим испытаниям ткани пассивного миокарда. Использованы образцы сердечной ткани 10 овец, которые в течение 3 часов после смерти были доставлены в лабораторию для биомеханических испытаний. Верхние области сердца над короткой осью были аккуратно изъяты. Образцы тканей были взяты из центральных областей левого и правого желудочков, межжелудочковой перегородки. Затем эпикард и эндокард осторожно срезали, чтобы выделить миокард. Были получены, обработаны и дискретизированы кривые «напряжения-деформации». Результаты показывают, что модели Чои-Вито и Фанга наилучшим образом подходят для левого желудочка, а модели Хольцапфеля (2000), Хольцапфеля (2005), полиномиальная (анизотропная) и four-fiber family - для правого желудочка.
Механика сердечной деятельности, экспериментальная механика, механика овечьего сердца, гиперупругие модели, подбор параметров моделей, механика мягких тканей, двухосевое механическое испытание
Короткий адрес: https://sciup.org/146282487
IDR: 146282487 | УДК: 531/534: | DOI: 10.15593/RZhBiomeh/2022.2.02
Fitting of hyperelastic constitutive models in different sheep heart regions based on biaxial mechanical tests
Heart failure remains one of the leading causes of death especially among people over the age of 60 years worldwide. To develop effective therapy and suitable replacement materials for the heart muscle it is necessary to understand its biomechanical behaviour under load. This paper investigates the passive mechanical response of the sheep myocardia excised from three different regions of the heart. Due to the relatively higher cost and huge ethical demands in acquisition and testing of real animal heart models, this paper evaluates the fitting performances of six different constitutive models on the myocardial tissue responses. Ten sheep were sacrificed, and their hearts were excised and transported within 3 hours to the testing biomechanical laboratory. The upper sections of the hearts above the short axes were carefully dissected out. Tissues were dissected from the mid-sections of the left ventricle, mid-wall and right ventricle for each heart. The epicardia and endocardia were then carefully sliced off each tissue to leave the myocardia. Stress-strain curves were calculated, filtered and resampled. The results show that Choi-Vito model was found to provide the best fit to the left ventricle, the polynomial (anisotropic) model to right ventricle, the Four-Fiber Family model to right ventricle, Holzapfel (2000) to right ventricle, Holzapfel (2005) to right ventricle and the Fung model to left ventricle.
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