Применение ниволумаба при раке толстой кишки с синдромом Линча. Клиническое наблюдение

Применение ниволумаба при раке толстой кишки с синдромом Линча. Клиническое наблюдение

Автор: Хакимова Г.Г., Трякин А. А., Хакимов Г. А.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Клинический случай

Статья в выпуске: 1 т.10, 2020 года.

Бесплатный доступ

Синдром Линча (СЛ), возникающий в результате нарушений репарации неспаренных оснований ДНК, характеризуется повышенным риском развития рака толстой кишки, эндометрия и мочевыводящих путей. Независимо от типа опухоли, иммунотерапия ингибиторами контрольных точек (ИКТ) была одобрена для лечения пациентов с неоперабельными или метастатическими опухолями с нарушением системы репарации ДНК (dMMR), что может быть опцией для лечения пациентов с СЛ. В статье описывается клиническое наблюдение пациентки с герминальной мутацией MLH1 и с первично-множественными злокачественными образованиями ободочной кишки, получавшей лечение ниволумабом в течение 26 месяцев. Это наблюдение демонстрирует успех иммунотерапии после 6 линий химиотерапии, подразумевая потенциальный контроль опухолевого роста у пациентов с СЛ.

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Иммунотерапия, рак толстой кишки, микросателлитная нестабильность, анти- pd-1-моноклональные антитела, ниволумаб, пембролизумаб

Короткий адрес: https://sciup.org/140251215

IDR: 140251215   |   DOI: 10.18027/2224-5057-2020-10-41-48

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