Application of direct endolymphatic ozone therapy in the treatment of purulent-necrotic complications of diabetic foot syndrome

Introduction. The high frequency of amputations at the level of the shin and hip in patients with purulent-necrotic complications of diabetic foot syndrome is an urgent medical and social problem.The purpose of the study. To evaluate the effectiveness of the method of direct antegrade endolymphatic ozone therapy in the complex treatment of patients with purulent necrotic lesions in the neuroischemic form of diabetic foot syndrome.Materials and methods of research. 107 patients with the neuroischemic form of diabetic foot syndrome were treated. Balloon angioplasty of the arteries of the affected lower limb was performed in block I, and endovascular correction of blood flow was not performed in block II patients. In each block of studies, the main group was identified, in which the method of direct antegrade endolymphatic ozone therapy was used, and the control group, where the developed method was not used.Treatment results. The patients of the main groups showed positive dynamics: in the I block, more than 80 % of patients noted the absence of pain or mild pain; in the II block - 65,2 %. In the main group of block I, compared with the control group, an increase in the duration of treatment was noted by 5,4 %, but the severity of operations was statistically less, 1,08 versus 1,39. Also, in the main groups, there was a decrease in the level of peripheral blood leukocytes and the degree of bacterial contamination of the wound.Conclusion. Direct endolymphatic application of ozonated solution allows to accelerate the relief of purulent-necrotic processes in patients with chronic lower limb ischemia with diabetic foot syndrome by stimulating the body's own enzyme systems, antihypoxic, antibacterial and detoxifying properties of ozone, reduces the number of high amputations.