Synthetic implant use based on hydroxyapatite and wollastonite to stimulate bone regeneration processes

The aim of the study is to evaluate the efficiency of using bone substitute material grounded on hydroxyapatite and wollastonite based on changing clinical status indicators, radiographic examination and hematological parameters. A preclinical study was conducted at the Faculty of Veterinary Medicine, Institute of Veterinary Medicine and Biomedical Sciences, Omsk State Agrarian University named after P.A. Stolypin. The object of the study was laboratory rabbits (n = 10) of the white New Zealand breed, HYCOLE genetics, aged (13 ± 1.2) months, weighing (4.78 ± 0.37) kg with a formed model of cortical bone defect of the femur in the distal metaphysis area. To evaluate the efficiency, the animals were divided into 2 groups. Animals for the study were selected using the analog method. In animals from group I, the defect cavity was closed with SiHA granules. Group II remained intact without replenishment of the cortical defect. The dynamics of reparative processes were monitored using clinical, biochemical and radiological studies. At all stages of observation, animals of group I were distinguished by relatively fast healing times and restoration of physiological indicators and support on the operated limb. X-ray examination showed tight contact of bone tissue with the SiHA and formation of bone intermedial callus in the defect area. According to the hematological study, an increase in the indicators of biochemical markers of osteogenesis in animals with replenishment of the bone defect of the SiHA was monitored, which indicates active regeneration processes. The data obtained give reason to assume the effectiveness of using the SiHA to stimulate reparative regeneration in animals with bone pathologies.