Pro/antioxidant activity of a new PIR-10 substance (pyrimidine derivative) under experimentally simulated focal cerebral iscemia in rats

The authors have performed a piece of research that focused on assessing anti-oxidant activity of PIR-10, a new pyrimidine derivative, as a risk factor causing disorders in the cerebral hemodynamics under experimentally simulated focal cerebral ischemia in rats. The experiment was accomplished on male Wistar rats with body weight equal to 220-240. 40 animals were distributed into 4 equal groups (n=10). The first group was made up of falsely operated animals; the second one was a negative control group; animals from both these groups were given a water suspension purified with TWEEN-80 in equivalent volumes. The third group included rats that were given a reference medication, namely Mexidol (emoxypine) (50 mg/kg). Animals from the fourth group were given an experimental substance with a laboratory cipher PIR-10 (50 mg/kg). All the examined objects were introduced intraperitoneally immediately after a surgery and during 3 days. Local cerebral ischemia was induced via coagulation of the left mesencephalic artery...